ABSTRACT
The resource utilization of castoff from Chinese materia medica (CMM) industrialization is an important measure to effectively improve the efficiency of resource utilization, save resources, recycle economy, and develop environment-friendly economy. Based on the conversion efficiency of resource utilization model of castoff from CMM industrialization, this article mentions the non-aqueous biotransformation method of herb-medicine castoff, discusses the suited non-aqueous biotransformation systems, and introduces the screening and application of organic-solvent-tolerant extremophiles and enzymes. This article points out that non-aqueous biotransfornation technology is a breakthrough in the resource utilization of castoff from CMM industrialization, and it would promote the realization of herb-medicine castoff resource utilization.
ABSTRACT
<p><b>AIM</b>To investigate the in vitro influencing factors on drug release from matrices with sodium alginate as the hydrophilic polymer.</p><p><b>METHODS</b>Sodium alginate hydrophilic matrix tablets were prepared by direct compression method with theopylline as a model drug. The in vitro influencing factors on drug release behavior from matrices were studied by investigating the swelling, water uptake and erosion characteristics of pure sodium alginate matrices.</p><p><b>RESULTS</b>The results showed that drug release rate and drug release mechanism were both related to the viscosity of sodium alginate used in matrices, pH values and ionic strength of dissolution media and rotation speeds.</p><p><b>CONCLUSION</b>Sodium alginate can be tailor-made to suit the demands of applicants in sustained delivery systems as a good candidate of hydrophilic polymer.</p>